Radiation induced lipid peroxidation pdf

Ionizing radiationinduced metabolic oxidative stress and. Lipid peroxidation was found to increase with increase in concentrations of ferrous ions fig. Protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Inhibition of radiationinduced lipid peroxidation by. Radiation induced peroxidative damage semantic scholar. Pdf scoparone inhibits ultraviolet radiationinduced lipid. Methylseleninic acid induces lipid peroxidation and radiation. Leaf extract of moringa oleifera prevents ionizing. Pdf protective effect of moringa oleifera leaf extract mole against radiation induced lipid peroxidation has been investigated. Radiationinduced lipid peroxidation triggers ferroptosis. Ionizing radiation is classified as either electromagnetic or particulate. Curcumin was incorporated into microsomes during ultracentrifugation. Pdf antioxidant capabilities of scoparone, the component of artemisia scoparia and other medicinal plants, against lipid peroxidation induced by. These results suggest that ferroptosis and lipid peroxidation contribute to radiationinduced cell death in ht1080 cells, and that this ferroptotic cell death can be enhanced by the addition of otherwise sublethal concentrations of ike or rsl3.

Pdf amelioration of ionizing radiation induced lipid peroxidation in. Amelioration of ionizing radiation induced lipid peroxidation. Request pdf radiation induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Swiss albino mice were administered mole 300 mgkg of body weight for 15 consecutive days before exposing them to a single dose of 5 gy of 60 co. Antioxidant activity of capsaicin on radiationinduced. The antioxidant has significant time and concentrationdependent inhibitory effect on lipid peroxidation induced by rradiation. The ability of curcumin, a natural antioxidant from turmeric, to inhibit radiationinduced lipid peroxidation in rat liver microsomes was examined. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for radiationinduced cancer cell death. Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of dna repair and inhibition of apoptosis. We have studied the effect of ferrous ions on radiation induced lipid peroxidation. Pdf influence of ferulic acid on gammaradiation induced.

It is the interaction of these radiationinduced free radicals with important biomolecules within the cell that is the basis of the cellular sensitivity to radiation. Request pdf radiationinduced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Inhibition of radiationinduced lipid peroxidation by tetrahydrocurcumin. Radiation induced lipid peroxidation in liposomes sciencedirect. Ionizing radiation is known to induce oxidative stress through generation of reactive oxygen species ros resulting in imbalance of the prooxidant and antioxidant activities ultimately resulting in cell death. Radiationinduced lipid peroxidation triggers ferroptosis and synergizes. Calmodulin antagonists also decreased the cytochrome p450 content of microsomes. Radiationinduced lipid peroxidation triggers ferroptosis and. Modulation of radiation induced lipid peroxidation by phospholipase. When the microsomes are irradiated in the presence of n20, the resulting lipid peroxidation is predominantly due to hydroxyl radicals. Ionizing radiation track structure and the nature of induced biological effects.

Topical antioxidant vitamins c and e prevent uvbradiation. Radiationinduced peroxidation and fragmentation of lipids. Selenium represents an adjuvant that selectively sensitizes cancer cells to these treatments modalities, potentially by inducing lipid peroxidation. Vitamin e and vitamin c completely protected against uvbradiationinduced lipid peroxidation p pdf 51 k pdf plus 97 k citing articles. Efforts are made to show similarities between radiolytic and. Lipid peroxidation after ionizing irradiation leads to apoptosis and. Ionizing radiation track structure and the nature of induced biological effects ionizing radiation is classified as either electromagnetic or particulate. Vitamin e and vitamin c completely protected against uvb radiation induced lipid peroxidation p induced a vitamin e consumption of up to 100% in the stratum corneum and viable epidermis, and a vitamin c consumption of only 21% in the stratum corneum. Additional methods and supplemental figures and tables pdf. Therefore, compounds that sensitize cancer cells to radiation via alternative cell death pathways are valuable. Effects of calmodulin antagonists on radiationinduced.